OPTIMASI FORMULA HAIR TONIC MIKROEMULSI BIOTIN (VITAMIN B7) DENGAN METODE FACTORIAL DESIGN

نویسندگان

چکیده

Loss becomes a problem in the hair that causes baldness. Biotin is vitamin nourishes and prevents loss. which formulated microemulsion tends to be transparent, has low viscosity high solubility. Formula optimization was carried out determine concentration of span 80, tween PEG 400 biotin tonic. The research conducted on an experimental basis using factorial design method with 3 factors, namely 400. optimum formula determined Design Expert 13 software Factorial method. Testing physical quality preparation at formula. Optimization tonic showed results 80 (20%), (9.466%) (5%) predicted 46.75 cPs globule size 2.98 µm. Prediction testing test compared One Sample T-test were not significantly different significance value >0.05. 47.67 2.4 obtained concluded optimal composition from combination produces good effects 20%, 9.47% 5%.

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ژورنال

عنوان ژورنال: JIIS (Jurnal Ilmiah Ibnu Sina): ilmu farmasi dan kesehatan

سال: 2023

ISSN: ['2503-1902', '2502-647X']

DOI: https://doi.org/10.36387/jiis.v8i1.1071